melanocortin receptor การใช้

• There are five known members of the melanocortin receptor system each with differing specificities for melanocortins:
• AGRP has been demonstrated to be an inverse agonist of melanocortin receptors, to be specific cells.
• Though the exact mechanism of action of Semax is unclear, there is evidence that it may act through melanocortin receptors.
• Both appear naturally in humans, and each binds melanocortin receptors 4 and 1 ( Mc1R ), respectively, with nanomolar affinities.
• ACTH receptors are the shortest of the melanocortin receptor family and are the smallest known G-coupled receptors . Both human and bovine ACTH receptors are synthesized as 297 residue long proteins.
• "' THIQ "'is a drug used in scientific research, which is the first non-peptide agonist developed that is selective for the melanocortin receptor subtype MC 4.
• "' PF-00446687 "'is a drug developed by Pfizer for the treatment of erectile dysfunction, which is a non-peptide agonist selective for the melanocortin receptor subtype MC 4.
• The alleles at the E locus ( the melanocortin receptor 1 gene or MC1R ) determines whether an animal expresses a melanistic mask or a grizzle overlay, as well as determining whether an animal expresses eumelanin in its coat.
• Specifically, there is a report of Semax competitively antagonizing the action of the melanocortin receptor full agonist ?-melanocyte-stimulating hormone ( ?-MSH ) at the MC 3 receptor, though this receptor could still be a target of the drug.
• *PT-141 is an analog of alpha-melanocyte-stimulating hormone ( alpha-MSH ) that activates the melanocortin receptors MC3-R and MC4-R . It indeed causes tanning but has some side-effects . . . Cacycle 13 : 23, 6 Apr 2005 ( UTC)
• The non-selective melanocortin receptor agonist afamelanotide ( NDP-?-MSH ) has been found to induce brain-derived neurotrophic factor ( BDNF ) expression in the rodent brain via activation of the MC 4 receptor and mediate " intense " neurogenesis and cognitive recovery in an animal model of Alzheimer's disease.
• When bound to ACTH, a short-term melanocortin receptors has been demonstrated in several types of test animals : rats and hamsters primarily respond to ACTH, rabbits respond to alpha and beta MSH's ( therefore not using the ACTH receptor ), and guinea pigs responding to both ACTH and other MSH's.
• While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC 4 subtype can produce similar aphrodisiac effects to older non-selective peptide-based melanocortin receptor agonists like melanotan II and bremelanotide, without the side effects caused by action at the other melanocortin receptor subtypes.
• While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC 4 subtype can produce similar aphrodisiac effects to older non-selective peptide-based melanocortin receptor agonists like melanotan II and bremelanotide, without the side effects caused by action at the other melanocortin receptor subtypes.
• The "'adrenocorticotropic hormone receptor "'or "'ACTH receptor "'also known as the "'melanocortin receptor 2 "'or "'MC 2 receptor "'is a type of melanocortin receptor ( type 2 ) which is specific for ACTH . It is a G-coupled receptor located on the external cell plasma membrane, and plays a role in immune function and glucose metabolism.
• The "'adrenocorticotropic hormone receptor "'or "'ACTH receptor "'also known as the "'melanocortin receptor 2 "'or "'MC 2 receptor "'is a type of melanocortin receptor ( type 2 ) which is specific for ACTH . It is a G-coupled receptor located on the external cell plasma membrane, and plays a role in immune function and glucose metabolism.